I like your set up expavr, you take "Dare to be different" to a new level.
PeterC gives some good tips and I will expand on what he said. I have a 6-71 on an overhead (yes, it's a Chevy) but this discussion needs all the input it can get so I will add my 2 cents.
Any short block for a blower application should have a quality piston; I'd invest in forged pistons and a modern ring package, rebuilt rods done by a competent shop and pay close attention to bottom end clearances and the oiling system. In my case I run 8.7-1 compression, but it is an overhead, I'd keep a flathead in the 6.5 to 7-1 range. I run my blower at 15% underdriven and it is a bit on the loose side, never more than 7 lbs. boost and it has two 600 Holleys on it with direct linkage, not progressive. The total timing is set at 28* and I run a fairly conservative camshaft with .445 lift and 222* duration @ .050. Reliability has never been a problem, I have not driven cross country but have gone to Oklahoma City two times from the Chicago area and done numerous other long distance road trips and never had any problems.
Build a reliable short block, maybe with the L100 cam that many here like, add the blower and start up with a reasonable amount of total timing, sneak up on the best total advance, not too much right off the bat. I would probably go with a 600 carburetor, but even with two Holleys on mine and direct linkage I have no concerns. Mileage on the road has been 17.5 mpg with 3.36 gears and a 31" tall tire. The engine will run like a stocker at idle and in normal driving; only when you give it some serious throttle will it get enough air to build boost and at that point hang on! Read all you can, plan out a good combination, and build for the street- leave the hard core race stuff and gearing out of the picture and you will see that performance, reliability and mileage can be had in one package.