I have the same question. My 'Touring' Engine was built by Ron Kelley. In his 'General Instructions', with the delivery of the new engine, he instructs "Inspect / Adjust valve clearances at 2,000 miles, to .012 / .014 on Intake valves, and .016 / .018 on Exhaust valves. INSPECT / ADJUST valves every 6,000 - 8,000 miles thereafter."
My 'Touring Engine' also has a cast iron Exhaust Header (goes with Cragar/Stromberg Intake manifold) that drops down low and covers 90% of my Valve Cover. I have not looked into 'special' tools, sockets, etc. to see if the Valve Cover can be removed WITHOUT first removing the Exhaust Header. But a quick glance says 'NOT A PRAYER'.
So that brings me back to the original question of Quigley1930's original post :
"Can I check the valve clearances with the manifolds in place . . . ?"