A negative pressure in the cab is a negative pressure, but that is not to say that a direct (or indirect hit) on a gasket or door edge might not push a little bit of abrasive/dust into the room.
Your vacuum does have to have air capacity beyond the capability of the blast nozzle. CFM requirements of different size nozzles can be deceiving - as can the capacity of a vacuum to remove it through the corrugated flex hose, fittings, filter, discharge pipe, etc.
And most vacuums are not rated in SCFM (or even CFM)
Joe K