You will get varying opinions on this subject, but here is my take. The driveshaft should NOT be in in a perfectly straight line from trans to rear end, even if it were possible. The joints at each end have to move a little to keep the bearings from sitting in one spot and wearing little grooves in the cross of the u-j0int. Generally accepted desired angles are 3 degrees or less. Sometimes it is necessary to exceed the 3 degrees and I have done it with no adverse consequences YET after 70,000 miles. The typical transmission points downward at the u-joint connection. The rear pinion flange should point upward an equal amount. Another way of stating it is that a line drawn from the ends of each shaft should be PARALLEL to each other.