Bottom line, a cam profile is designed to run on a lifter of a certain diameter. If a cam is designed for a 1" lifter and you put in a 1.25" lifter, it will not do a dang thing. It will contact the 1.25" lifter at the same diameter and same way that it does a 1.00" lifter.
The only case where this is not true is if the cam profile "runs off the edge of the lifter" - which it should not really do (if designed correctly). On the original Potvin 425 cam, it DID run off the edge of the lifter a bit (which is hard on the cam and lifters). If you've ran one for a while and take a look at the outer edge of your lifters, you'll see what I mean.
I was in contact with Harvey Crane before he passed and he mapped my Potvin 425 on his machine and used his super-sophisticated computer program to rework the profile, so it didn't run off the lifter edge. We were going to regrind a new version of the Potvin 425, but as life/luck had it . . . Harvey passed away. The super-bad part of this story is that my original Potvin 425 went to the grave with him! Argggghhh
Harvey was a super good dude and had a lot of good stories to tell about the "cam wars" back in the day, how he and Ed Isky got along (and did business together), etc.. I miss both of those guys!