I'm not surprised by this. IIRC, it is 2 and 3 that tend to have the 'best' combustion. One of the period aftermarket ads supposedly showed the advantage of a particular brand of manifolds (likening it to kerosene lamps out of adjustment which has some parallel basis in fact similarities.)
Still, though why No. 3 and not No. 2 the same. Is No. 2 a bit "lighter" than No. 1 and 4?
I think part of this difference is temperature. When cracks occur they seem to occur mostly on No. 2 and No. 3 valve seats, most frequently on the exhaust. But the temperature (and your hand on the GAV) probably the most direct effect on combustion efficiency.
It may be how you adjust your GAV? Maybe a little heavier on the mix? Too light tends to make for incomplete combustion and heat at the exhaust. But then again, go too rich and you're fighting the two outer cylinders and possibly making them MORE carbonaceous.
I would say if you're not seeing obvious problems with water in the crankcase, or excessive vapor out the exhaust, or bubbles in the cooling water neck then just keep driving it. It will tell you for sure when you've screwed up.
Joe K