I can tell you from experience it WILL cause a problem.
On the 33 original babbit engine that we used in the 33 for a long time.
I had it rebuilt but used the best old valves and guides.(dumb)
We we to a national rally that was 1000 miles each way.
On the way home the engine got a little bit rough.not much but not as smooth as usual.
When we got home I parked it in the shed ,commenting how well it went on the trip.
the next week I started it up and promply turned it off,It sounded like it had hammers tied to the crankshaft,
I thought it had some of the sleeves (it was sleeved back to standard) come loose.
I took the engine out and just heaved it under the bench and fitted another spare engine .
Some months later I took the heads off the babbit engine to have a look,the tops of the pistons were all carboned up as well as the head,and the pistons hit this carbon and thats what the noise was.
I later I cleaned it off,fitted new straight valves and guides with seals on the inlet and reused this engine for a long time,it is still the smoothest one I have.
Lawrie