The Bugatti engines had a roller-bearing crankshaft, and the big end of the connecting rods were one piece, meaning each section of the crank had to be assembled in place. This allowed high rev limits, and took advantage of the relatively low cost of labor compared to the cost of materials.
The downside of this method was revealed when a section of the crank failed.
If I recall an article about the prewar Bugattis (Automobile Quarterly?) the heads were not removable, but one piece with the block. No head gasket needed, but if a piston required removal it had to be done from underneath. Perhaps it was the same article which talked about the Bugatti Club tours, and cited the fragility of the camshafts as the reason why one of the club members travelled with an extra set, wrapped in oiled cloth in case a roadside replacement was needed.
A nice Model A block with overhead valve head and dual carbs sounds like a rational alternative.