Most folks use the outline of the gasket for their relief - though there are different "styles" of reliefs. The Offy heads do have a different shape on the exhaust sides of the chamber which is a bit strange in that even with a stock block, this creates a channel underneath that area. This was probably done to increase compression . . . as I don't see it helping flow.
Notice the chamber shape difference in these Navarro heads (made by Barney):
If you desire more CC's in your chambers (due to a blower), then I would modify the Offy shape to more closely follow the gasket pattern (more like what most other head manufacturer's do) - as noted above. At the very least, radius the sharp edges that are hanging out in the chamber.
If it was my engine and I was putting a supercharger on it, I would modify the chamber to match the gasket and the relief would as well. My relief is usually .125 to .187 deep. I'd probably use a .125 deep relief on your setup.
One thing to note with a blown engine is where is the top ring on the piston? With a deeper relief, the top ring is closer to the bottom of the relief and will take on more heat. On blower pistons I have the manufacturer lower the ring package a bit - to take some heat out of the top ring.
If you're ordering your pistons from Ross, they can move the ring package for you a bit (down). Also, check the shape of your chambers as they relate to your piston crowns. I've not had a set of new/stock Offy heads in years - do they have a consistent radius in the dome (like Ross pistons) or a pointier shape in the middle - which is caused by multiple elliptical shapes converging. There are two basic dome shapes - one tends to follow the stock Ford cast pistons and the other aftermarket pistons like Ross.
If you have the more "pointy" shaped domes and run the consistent radius pistons, then the quench will be inconsistent over the piston crowns . . . something I don't like.
On a custom-built engine (what I do) I make sure I match the head dome shapes to my piston crown shapes to achieve a .040 quench.
To achieve this, it usually requires either custom head work, custom piston compression heights . . . or both.