It doesn't take much drain to kill a battery. In a seldom used vehicle, an electric clock will do it if the fuse isn't pulled. The best defense is a battery cutoff switch. On old cars, putting a bulb or voltmeter between the cable and the battery will show a "parasitic" loss, and you have to disconnect portions of the system until it is found. We can't do that on newer cars because the battery keeps the ECM (engine computer) alive at all times. We recently had a Cadillac Escalade come into our shop. The battery would go dead in a couple of days. The dealer had replaced the battery and the alternator to no avail, and sent it to us. After considerable head scratching, and some luck, we found that the dimming circuit in the far back dome light wasn't fully releasing, even after the bulb stopped shining. If we hadn't seen it before we, too, would have been stumped.