Hey GB, the issue becomes how far down is the adjuster as compared to the top of the lifter body. If there is enough room, then a jamb-nut can be used, if there is not, then you can't fit one in (and still get a wrench on it). With a high-lift cam, the base-circle of the cam is much smaller, so the adjuster needs to be much further out. While this gives you room for a jamb nut, it also means there are a lot less threads engaged in the lifter body.
Having the adjuster way out creates a problem for many folks - the adjuster is much further out than if used with a stock base-circle cam. This tends to result in less threads in "interference mode" and the adjusters are now too loose . . . and they become looser after the engine is running (they always back down, not up).
To deal with these issues I run longer valves with high-lift cams - so the adjuster does not have to be threaded way out to take up the slack . . . the longer valve (stock SBC length) does it for me. But now this creates a problem where the installed height of the spring has increased - so I don't have the spring pressure I need. (Always seems there are compound effects with this stuff!)
Fix for the Spring Height Issue: When I run the longer valves, I also take an aftermarket Crane retainer (for OHV double valve springs) and cut it down for my single flathead springs. These retainers are a lot thicker than stock, so they take up the extra space/length for the overall valve spring installed height. This trick means I don't have to run a bunch of .060 spring shims on the guide to achieve the spring pressure I need on the seat.
Hope I'm making some geometric sense here.
Just a bunch of tricks to give me the best setup for high-lift cams (.375 and over). If anybody wants to know more, let me know.
Take care,
B&S