Many years ago i owned a company that had several F350 9' flat bed trucks. One of the trucks was the first F350 we purchased, it was a '64 V8 4sp, last year to have solid I beam front axle and the wide 5 lug bolt pattern. The wheels were 16" dual rear axle w/750 x 16 tires. We purchased the truck used so what we bought it what we got. We also had a couple of '64 Ford F250's, V8 4spd with 750 x 16 8 lug wells.
The truck was a very good truck, quite slow, turning a lot or RPM's at 55/60 mph. Over a period of several years we had a lot of engine trouble with the '64 F 350, we were lucky to get 50K out of an engine. The last 292 we put in the truck was a new Ford rebuilt, it grenaded with less than 30k on it.
We re-powered the truck with a low mileage 76 360 which was the same power plants our other F350's had. I had purchased the other F350's new so I knew that the gear ratio was 4.10 with 750 x 16 tires, 8 lug Firestone split rims.
We checked the gear ratio on the '64, assuming it would be 4.56, a standard gear ratio for F250/350'S during the early/mid '60's. To our surprise the '64 had 5.13 gears, no wonder we could not keep engines together in the truck.
I found a later model Ford F350 dual wheel rear end that was 4.10. We swapped out the old rear end for the 4.10, purchased 8 lug 16" spit rims and ran the truck for five more years, the next owner ran it for another ten years.
I don't recall how we handled the front end, I would guess that we swapped in a '64 F250 axle which would have been a bolt in application.
As time went bye I sold the '64 5.13 rear end to a man that had a Ford F350 off road welding truck, the 5.13 ratio worked very well for him.
Foot Note! In 1980/81 we switched all of our trucks from tube type split rims to tubeless radial tires, ending tube failure and constant flat tires.