There's likely only one safe way since I'm assuming that you want to remove the spring from the rear axle assembly and that your shackle links are more or less stock and that is to use a spring spreader. You can then do it with the spring still attached to the rear cross member or with it unattached to the cross member dropped down with the rest of the axle assembly although I would not recommend the former alternative as the weight of the rear axle will greatly increase the amount of side-to-side force necessary to relieve the spring tension enough to remove the shackles from the spring and adjacent spring perches on the rear axle housings with zero tension on the shackles.
As Mike wrote, there' a lot of tension in a rear spring and even more so in a 12 or 13 leaf original commercial chassis rear spring such as that likely in your pickup.